Salmonella is an important pathogen for both humans and animals. [com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/author/10.1128/9781555815639.ch29-1,webId=/content/author/10.1128/9781555815639.ch29-1,properties={foaf_givenname=Rafael, foaf_name=Rafael Rotger, foaf_surname=Rotger, pub_isAffiliatedWith=[com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/affiliation/10.1128/9781555815639.ch29-aff1]]}]][com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/author/10.1128/9781555815639.ch29-1,webId=/content/author/10.1128/9781555815639.ch29-1,properties={foaf_givenname=Rafael, foaf_name=Rafael Rotger, foaf_surname=Rotger, pub_isAffiliatedWith=[com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/affiliation/10.1128/9781555815639.ch29-aff1]]}]]eventtype:PERSONALISATION;jsessionid:Q1H4QDd8OXFtxiUMjIRFpSA4.asmlive-10-241-2-54;itemid:http://asm.metastore.ingenta.com/content/book/10.1128/9781555815639.ch29;timestamp:1596390031598Evolutionary Biology of Bacterial and Fungal Pathogens — Recommend this title to your libraryPlease check the format of the address you have entered.Approval was partially successful, following selected items could not be processed due to error The E. coli long-term evolution experiment (LTEE) is an ongoing study in experimental evolution led by Richard Lenski that has been tracking genetic changes in 12 initially identical populations of asexual Escherichia coli bacteria since 24 February 1988. Although the organism has been intensively studied during the last century, much remains to be learned about this pathogen. Studies of the relationships between different groups of bacteria continue to yield new insights into the origin of life on Earth and mechanisms of evolution. S. enterica is the type species and is further divided into six subspecies that include over 2,600 serotypes. Cattle isolates were in both first order clades (11 in clade α 7 in clade β), but in clade β they had a relatively limited distribution with five of the isolates from a subclade containing the DT204/49 complex of strains associated with a cattle associated epidemic in the 1970’s [To estimate the coverage of clinical isolates from the UK and global The presence of multiple third-level clades associated with recent livestock associated epidemic strains in the first level clade α and the relative paucity in clade β suggested that they may be under differential anthropogenic selection pressure. Most of the approximately 2500 serovars cause gastroenteritis in humans and other animals, while some have evolved host adaptation associated with extra intestinal disseminated infections in specific host species . /docserver/preview/fulltext/10.1128/9781555815639/9781555814144_Chap29-1.gif/docserver/preview/fulltext/10.1128/9781555815639/9781555814144_Chap29-2.gifThe PhoP/PhoQ system controls the intramacrophage type three secretion system of Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.Modulation and utilization of host cell phosphoinositides by Characterization of the ysa pathogenicity locus in the chromosome of Molecular characterization of emergent multiresistant Multiple resistance mechanisms in fluoroquinolone-resistant Characterization of a self-transferable plasmid from Detection of integrons and antibiotic-resistance genes in Targeting of the actin cytoskeleton during infection by Plasmid-encoded functions compensate for the biological cost of AmpC overexpression in a clinical isolate of Mucosal innate immune response to intragastric infection by Identification and functional characterization of chicken Toll-like receptor 5 reveals a fundamental role in the biology of infection with Host adaptation and the emergence of infectious disease: the Molecular characterisation of an outbreak strain of multiresistant Propagation of TEM- and PSE-type beta-lactamases among amoxicillin-resistant Increasing prevalence of quinolone resistance in human nontyphoid Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Integron- and carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Complementary activities of SseJ and SifA regulate dynamics of the Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42.Flagella and chemotaxis are required for efficient induction of Extended-spectrum beta-lactamases: implications for the clinical microbiology laboratory, therapy, and infection control.Elimination of host cell PtdIns(4,5)P2 by bacterial SigD promotes membrane fission during invasion by The emergence of multidrug resistance to antimicrobial agents for the treatment of typhoid fever.Efficacy trial of Vi polysaccharide vaccine against typhoid fever in south-western China.
A new step in the evolution of Salmonella could be gained by acquisition of the pathogenicity island SPI-2, a region of 40 kb composed of at least two distinct elements. It includes the gene Taken together, the suite of horizontally acquired virulence genes found across the SPIs act in a concerted fashion to drive infection, as Horizontal gene transfer drives bacterial evolution by introducing large amounts of genetic variation in single events, giving rise to adaptation occurring in what many refer to as “quantum leaps” (Although, the acquisition of genes through horizontal transfer has been essential to the evolution of Seminal work over the past decade has identified H-NS, a DNA binding protein conserved across Gram-negative bacteria, as a broad repressor of horizontally acquired genes (While H-NS is the most widely known silencer of virulence gene expression, it does not act alone upon horizontally acquired genes. CT is supported by a Postgraduate Scholarship from the Natural Sciences and Engineering Research Council of Canada. Salmonella is a bacterial pathogen with remarkable diversity in its host range and pathogenicity due to past within-host evolution in vertebrate species that modified ancestral mechanisms of pathogenesis.. Phylogenetic reconstruction is often sufficient to reveal the absence of genes when related species are compared to their last common ancestor. Significance.
Evolution of Salmonella Pathogenesis The genus Salmonellacomprises over 2500 serovars in two species, S. bongoriand S. enterica; the latter contains subspecies I, II, IIIa, IIIb, IV, VI, and VII.